曾谷城，博士，91吃瓜 教授，博士生导师。本科毕业于暨南大学，博士毕业于美国伊利诺大学。科研工作聚焦开发抗结核新技术，取得如下创新成绩：（1）系统阐述了长非编码RNA介导的T细胞抗结核感染免疫紊乱机制，为揭示结核病理深层机制提供了重要科学基础；（2）明确了Th1/CTL/Vγ2Vδ2 T细胞组合是抗结核保护性靶向细胞亚群，发现了增强抗结核感染的肠道共生菌与代谢物，开拓了靶向肠道干预的结核防治新路径，为解决结核防治难题提供了科学新思路。

学术成果

  1. Chen, L., Zhang, G., Li, G., Wang, W., Ge, Z., Yang, Y., He, X., Liu, Z., Zhang, Z., Mai, Q., Chen, Y., Chen, Z., Pi, J., Yang, S., Cui, J., Liu, H., Shen, L., Zeng, L., Zhou, L., Chen, X., … Zeng, G. (2022). Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis. Nature metabolism, 4(3), 359–373. 
  2. Yang, F., Yang, Y., Chen, L., Zhang, Z., Liu, L., Zhang, C., Mai, Q., Chen, Y., Chen, Z., Lin, T., Chen, L., Guo, H., Zhou, L., Shen, H., Chen, X., Liu, L., Zhang, G., Liao, H., Zeng, L., & Zeng, G. (2022). The gut microbiota mediates protective immunity against tuberculosis via modulation of lncRNA. Gut microbes, 14(1), 2029997. 
  3. Chen, Y., Mai, Q., Chen, Z., Lin, T., Cai, Y., Han, J., Wang, Y., Zhang, M., Tan, S., Wu, Z., Chen, L., Zhang, Z., Yang, Y., Cui, T., Ouyang, B., Sun, Y., Yang, L., Xu, L., Zhang, S., Li, J., … Zeng, G. (2023). Dietary palmitoleic acid reprograms gut microbiota and improves biological therapy against colitis. Gut microbes, 15(1), 2211501. 
  4. Pi, J., Zhang, Z., Yang, E., Chen, L., Zeng, L., Chen, Y., Wang, R., Huang, D., Fan, S., Lin, W., Shen, H., Xu, J. F., Zeng, G., & Shen, L. (2022). Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection. Journal of nanobiotechnology, 20(1), 36. 
  5. Pi, J., Shen, L., Yang, E., Shen, H., Huang, D., Wang, R., Hu, C., Jin, H., Cai, H., Cai, J., Zeng, G., & Chen, Z. W. (2020). Macrophage-Targeted Isoniazid-Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli. Angewandte ChemieInternational Edition, 59(8), 3226–3234. 
  6. Li, G., Yang, F., He, X., Liu, Z., Pi, J., Zhu, Y., Ke, X., Liu, S., Ou, M., Guo, H., Zhang, Z., Zeng, G., & Zhang, G. (2020). Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients. Microbes and infection, 22(3), 119–126.
  7. Zhou, J., Hu, Z., Wang, L., Hu, Q., Chen, Z., Lin, T., Zhou, R., Cai, Y., Wu, Z., Zhang, Z., Yang, Y., Zhang, C., Li, G., Zeng, L., Su, K., Li, H., Su, Q., Zeng, G., Cheng, B., & Wu, T. (2024). Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome, 12(1), 193. 
  8. Wu, S., Shan, Z., Xie, L., Su, M., Zeng, P., Huang, P., Zeng, L., Sheng, X., Li, Z., Zeng, G., Chen, Z., & Chen, Z. (2022). Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network. Advanced science, 9(3), e2103608. 
  9. Wang, Y., Zhong, H., Xie, X., Chen, C. Y., Huang, D., Shen, L., Zhang, H., Chen, Z. W., & Zeng, G. (2015). Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. PNAS, 112(29), E3883–E3892. 
  10. Pi, J., Shen, L., Shen, H., Yang, E., Wang, W., Wang, R., Huang, D., Lee, B. S., Hu, C., Chen, C., Jin, H., Cai, J., Zeng, G., & Chen, Z. W. (2019). Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency. Materials science & engineering. C, Materials for biological applications, 103, 109777. 

科研项目

1、2016/12/1~2019/11/30国家重点研发计划，靶向长链非编码RNA的多耐药结核控制，项目负责人

2、2016/1/1~2018/12/31国家自然科学基金-国家优秀青年，结核的免疫调控机制，项目负责人

3、2021/1/1~2024/12/31国家自然科学基金-面上项目，纳米硒缓释棕榈油酸靶向“肠-肺轴”的抗结核免疫功能与机理，项目负责人

4、2024/1/1~2027/12/31国家自然科学基金-面上项目，结核中肠道共生脆弱拟杆菌调节肺免疫稳态的功能与表观遗传机制，项目负责人

5、2025/1/1~2027/12/31深圳市医学研究专项，阿克曼菌驱动肠-肺迁移性T细胞抗结核的功能与机理，91吃瓜 项目负责人